The Beverly Hills 90210 and Riverdale actor passed away after suffering from a stroke.
Luke Perry suffered a major stroke last Wednesday and had been in an induced coma ever since.
His publicist confirmed his death earlier this morning.
He leaves behind his two children Jake, 21, and Sophie, 18.
They were with him at his bedside with his ex-wife Minnie Sharp and fiance Wendy Madison Bauer.
Perry suffered an earlier health scare in 2015 when pre-cancerous growths were found during a colonoscopy.
He was just 24 when he landed his breakout role in Beverly Hills 90210 playing bad boy Dylan McKay.
His most recent notable role was Fred Andrews on teen hit drama Riverdale.
Production on the show has been temporarily suspended after his shock death.
18-year-old male from Lakelands charged over incident in Pinjarra
BREAKING: Reports of a man armed with a firearm in the Pinjarra area
Hayden Ballantyne signs with Rockingham Rams
Mayor reassures community that 'no decision has been made' to close 4WD access at Tim's Thicket, White Hills beaches
DBCA 'sick and tired' of illegal access to Port Kennedy Scientific Park
Mandurah homeless camp goes up in flames
Dawesville community shocked after kangaroo deliberately mowed down
Teens armed with knife, scooter charged over Rockingham Shopping Centre fight
Mandurah private school teacher charged with alleged sexual abuse of male student